RANGAP1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Cell lysate)
RANGAP1 MaxPab polyclonal antibody. Western Blot analysis of RANGAP1 expression in Jurkat.
Western Blot (Transfected lysate)
Western Blot analysis of RANGAP1 expression in transfected 293T cell line (H00005905-T01) by RANGAP1 MaxPab polyclonal antibody.
Lane 1: RANGAP1 transfected lysate(64.57 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to RANGAP1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to RANGAP1 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human RANGAP1 protein.
Immunogen
RANGAP1 (NP_002874.1, 1 a.a. ~ 587 a.a) full-length human protein.
Sequence
MASEDIAKLAETLAKTQVAGGQLSFKGKSLKLNTAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEKVVSAFLKVSSVFKDEATVRMAVQDAVDALMQKAFNSSSFNSNTFLTRLLVHMGLLKSEDKVKAIANLYGPLMALNHMVQQDYFPKALAPLLLAFVTKPNSALESCSFARHSLLQTLYKV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88); Rat (90)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
RANGAP1 MaxPab polyclonal antibody. Western Blot analysis of RANGAP1 expression in Jurkat.Western Blot (Transfected lysate)
Western Blot analysis of RANGAP1 expression in transfected 293T cell line (H00005905-T01) by RANGAP1 MaxPab polyclonal antibody.
Lane 1: RANGAP1 transfected lysate(64.57 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to RANGAP1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]Immunofluorescence
Immunofluorescence of purified MaxPab antibody to RANGAP1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — RANGAP1
Entrez GeneID
5905GeneBank Accession#
NM_002883.2Protein Accession#
NP_002874.1Gene Name
RANGAP1
Gene Alias
Fug1, KIAA1835, MGC20266, SD
Gene Description
Ran GTPase activating protein 1
Omim ID
602362Gene Ontology
HyperlinkGene Summary
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq
Other Designations
OTTHUMP00000028918|segregation distorter homolog|segregation distortion
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Interactome
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