RANGAP1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
RANGAP1 transfected lysate.
Western Blot
Lane 1: RANGAP1 transfected lysate ( 63.5 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-RANGAP1 full-length
Host
Human
Theoretical MW (kDa)
63.5
Interspecies Antigen Sequence
Mouse (88); Rat (90)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-RANGAP1 antibody (H00005905-B01) by Western Blots.
SDS-PAGE Gel
RANGAP1 transfected lysate.
Western Blot
Lane 1: RANGAP1 transfected lysate ( 63.5 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — RANGAP1
Entrez GeneID
5905GeneBank Accession#
NM_002883.2Protein Accession#
-Gene Name
RANGAP1
Gene Alias
Fug1, KIAA1835, MGC20266, SD
Gene Description
Ran GTPase activating protein 1
Omim ID
602362Gene Ontology
HyperlinkGene Summary
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq
Other Designations
OTTHUMP00000028918|segregation distorter homolog|segregation distortion
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