RANGAP1 recombinant monoclonal antibody, clone R03-1F8
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More Files
- More Functions
Western Blot
Western blot analysis of 3T3 whole cell lysate with RANGAP1 recombinant monoclonal antibody, clone R03-1F8 (Cat # RAB04455).
Western Blot
Western blot analysis of Lane 1: HeLa whole cell lysate, Lane 2: A549 whole cell lysate, Lane 3: HL-60 whole cell lysate, Lane 4: U2OS whole cell lysate and Lane 5: C6 whole cell lysate with RANGAP1 recombinant monoclonal antibody, clone R03-1F8 (Cat # RAB04455).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human RANGAP1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human RANGAP1.
Theoretical MW (kDa)
Calculated MW: 64 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, 150mM NaCl, pH 7.4 (40% glycerol, 0.05% BSA and 0.01% Sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of 3T3 whole cell lysate with RANGAP1 recombinant monoclonal antibody, clone R03-1F8 (Cat # RAB04455).Western Blot
Western blot analysis of Lane 1: HeLa whole cell lysate, Lane 2: A549 whole cell lysate, Lane 3: HL-60 whole cell lysate, Lane 4: U2OS whole cell lysate and Lane 5: C6 whole cell lysate with RANGAP1 recombinant monoclonal antibody, clone R03-1F8 (Cat # RAB04455).Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — RANGAP1
Entrez GeneID
5905Protein Accession#
P46060Gene Name
RANGAP1
Gene Alias
Fug1, KIAA1835, MGC20266, SD
Gene Description
Ran GTPase activating protein 1
Omim ID
602362Gene Ontology
HyperlinkGene Summary
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq
Other Designations
OTTHUMP00000028918|segregation distorter homolog|segregation distortion
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