PKN1 MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Tissue lysate)
PKN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PKN1 expression in mouse testis.
Western Blot (Cell lysate)
PKN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PKN1 expression in K-562.
Western Blot (Transfected lysate)
Western Blot analysis of PKN1 expression in transfected 293T cell line (H00005585-T01) by PKN1 MaxPab polyclonal antibody.
Lane 1: PKN1 transfected lysate(103.9 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of PKN1 transfected lysate using anti-PKN1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with PKN1 purified MaxPab mouse polyclonal antibody (B01P) (H00005585-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PKN1 protein.
Immunogen
PKN1 (AAH40061.1, 1 a.a. ~ 942 a.a) full-length human protein.
Sequence
MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDISNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
Host
Rabbit
Reactivity
Human, Mouse
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PKN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PKN1 expression in mouse testis.Western Blot (Cell lysate)
PKN1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PKN1 expression in K-562.Western Blot (Transfected lysate)
Western Blot analysis of PKN1 expression in transfected 293T cell line (H00005585-T01) by PKN1 MaxPab polyclonal antibody.
Lane 1: PKN1 transfected lysate(103.9 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of PKN1 transfected lysate using anti-PKN1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with PKN1 purified MaxPab mouse polyclonal antibody (B01P) (H00005585-B01P). -
Gene Info — PKN1
Entrez GeneID
5585GeneBank Accession#
BC040061.1Protein Accession#
AAH40061.1Gene Name
PKN1
Gene Alias
DBK, MGC46204, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Gene Description
protein kinase N1
Omim ID
601032Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
protein kinase C-like 1|protein kinase C-like PKN|protein kinase C-related kinase 1|serine-threonine kinase N|serine/threonine protein kinase N
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Interactome
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Disease
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