Products

Western Blot (Transfected lysate)

Western Blot analysis of PPM1B expression in transfected 293T cell line (H00005495-T01) by PPM1B MaxPab polyclonal antibody.

Lane 1: PPM1B transfected lysate(52.60 KDa).
Lane 2: Non-transfected lysate.

In situ Proximity Ligation Assay (Cell)

Proximity Ligation Analysis of protein-protein interactions between PPM1B and CHUK. HeLa cells were stained with anti-PPM1B rabbit purified polyclonal 1:1200 and anti-CHUK mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Entrez GeneID

5495

GeneBank Accession#

NM_002706.4

Protein Accession#

NP_002697.1

Gene Name

PPM1B

Gene Alias

MGC21657, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX

Gene Description

protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform

Omim ID

603770

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq

Other Designations

OTTHUMP00000158953|OTTHUMP00000158955|protein phosphatase 1B|protein phosphatase 2C beta isoform|protein phosphatase 2C-like protein