ITGB2 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ITGB2.
Immunogen
A synthetic peptide corresponding to N-terminus of human ITGB2.
Host
Rabbit
Theoretical MW (kDa)
84.7
Reactivity
Human
Specificity
The synthetic peptide of this antibody different from the related mouse sequence by five amino acids.
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of MMP16 on formalin fixed, paraffin embedded human uroepithelium cancer with ITGB2 polyclonal antibody (Cat # PAB12294). -
Gene Info — ITGB2
Entrez GeneID
3689Protein Accession#
AAH05861Gene Name
ITGB2
Gene Alias
CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7
Gene Description
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
CD18 subunit|OTTHUMP00000115278|OTTHUMP00000115279|OTTHUMP00000115281|OTTHUMP00000115282|beta 2 integrin subunit|cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta 2|integrin bet
-
Interactomes
-
Pathways
-
Diseases
-
Publication Reference
-
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, Hogg N.
The Journal of Clinical Investigation 2003 Jan; 111(1):51.
Application:Flow Cyt, WB-Ce, Human, T cells, Neutrophils.
-
The gene organisation of the human beta 2 integrin subunit (CD18).
Weitzman JB, Wells CE, Wright AH, Clark PA, Law SK.
FEBS Letters 1991 Dec; 294(1-2):97.
-
The expression of CD18 is increased on Trisomy 21 (Down syndrome) lymphoblastoid cells.
Taylor GM, Williams A, D'Souza SW, Fergusson WD, Donnai D, Fennell J, Harris R.
Clinical and Experimental Immunology 1988 Feb; 71(2):324.
Application:Flow Cyt, Human, Human lymphoblastoid cells.
-
A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com