Products

Western Blot

Immunofluorescence

Immunofluorescent staining of Jurkat cells with ITGB2 recombinant monoclonal antibody, clone 60.3 (Cat # RAB03179).
Immunofluorescence analysis of paraformaldehyde fixed Jurkat cells on Shi-fix™ coverslips stained with the chimeric r version of RAB03179 at 10 ug/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/ml)- showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right- top-bottom RAB03179- DAPI- merged channels and an isotype control. The isotype control was an unknown specificity antibody (3.0) followed by staining with Alexa Fluor® 488 secondary antibody.

Enzyme-linked Immunoabsorbent Assay

Inhibition Assay

Blocking

Entrez GeneID

3689

Gene Name

ITGB2

Gene Alias

CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7

Gene Description

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

Omim ID

116920 600065

Gene Ontology

Hyperlink

Gene Summary

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq

Other Designations

CD18 subunit|OTTHUMP00000115278|OTTHUMP00000115279|OTTHUMP00000115281|OTTHUMP00000115282|beta 2 integrin subunit|cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)|complement receptor C3 beta-subunit|integrin beta 2|integrin bet