Apoptosis is the process of programmed cell death. It is used to dispose non-needed cells by multicellular organisms. In the process of cell death, apoptosis involves series of biochemical events in a cell, including cell shrinkage, chromatin condensation, membrane blebbing, nuclear collapse and DNA fragmentation. Some of those events can be used to detect the occurrence of apoptosis.
Apoptosis plays an important role in embryonic development and many diseases such as cancer. It has become a hot research field and many detection methods have been established. Listed below are some features that can be used to detect apoptosis:
- Caspase activation
- Annexin V binding
- Mitochondrial membrane potential change
- DNA fragmentation
- Cytochrome c release
Abnova provides the research tools, including antibodies, antibodies array, proteins, chimera RNAi, ELISA and assay kits for apoptosis research.
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