Products

Western Blot (Cell lysate)

Western blot analysis of K562 (A), C6 (B), NIH3T3 (C), Hela (D) whole cell lysates with FLT1 recombinant monoclonal antibody (Cat # RAB02554).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of human colon cancer formalin fixed paraffin embedded tissue section using FLT1 recombinant monoclonal antibody (Cat # RAB02554). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.63). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Immunoprecipitation

Entrez GeneID

2321

Protein Accession#

P17948

Gene Name

FLT1

Gene Alias

FLT, VEGFR1

Gene Description

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Omim ID

165070

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia

Other Designations

fms-related tyrosine kinase 1|soluble VEGF receptor 1-14|soluble VEGFR1 variant 2|soluble VEGFR1 variant 21|vascular endothelial growth factor/vascular permeability factor receptor