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CLEC4M recombinant monoclonal antibody, clone 16E7

  • Catalog # : RAB00096
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  • Specification
  • Product Description:
  • Recombinant rabbit monoclonal antibody raised against human CLEC4M.
  • Immunogen:
  • Original antibody is raised against human CD299.
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human CLEC4M, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.
  • Form:
  • Liquid
  • Purification:
  • Protein A affinity purification
  • Isotype:
  • IgG, kappa
  • Recommend Usage:
  • Flow Cytometry (1 ug/mL)
    Immunohistochemistry (5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.02% Proclin 300).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Antibody Species:
  • Rabbit
  • Applications
  • Immunohistochemistry
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry
  • Flow Cytometry
  • Gene Information
  • Gene Name:
  • CLEC4M
  • Gene Alias:
  • CD209L,CD299,DC-SIGN2,DC-SIGNR,DCSIGNR,HP10347,L-SIGN,LSIGN,MGC129964,MGC47866
  • Gene Description:
  • C-type lectin domain family 4, member M
  • Gene Summary:
  • This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants
  • Other Designations:
  • CD209 antigen-like,CD299 antigen,dendritic cell-specific ICAM-3-grabbing nonintegrin 2,liver/lymph node-specific ICAM-3 grabbing non-integrin,mannose binding C-type lectin DC-SIGNR
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