TNF humanized monoclonal antibody, clone cA2 (Infliximab)
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Specification
Product Description
Humanized recombinant monoclonal antibody raised against human TNF.
Antibody Species
Human
Immunogen
Original antibody is raised against recombinant protein corresponding to human TNF.
Reactivity
Human
Specificity
This antibody binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.
Form
Liquid
Purification
Protein A affinity purification
Isotype
Human IgG1, kappa
Recommend Usage
ELISA (0.1 ug/mL)
Flow Cytometry (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.02% Proclin 300)
Storage Instruction
Store at 4°C for up to 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This is a chimeric antibody created for improved compatibility with existing reagents, assays and techniques.
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Applications
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — TNF
Entrez GeneID
7124Protein Accession#
P01375Gene Name
TNF
Gene Alias
DIF, TNF-alpha, TNFA, TNFSF2
Gene Description
tumor necrosis factor (TNF superfamily, member 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq
Other Designations
APC1 protein|OTTHUMP00000029281|OTTHUMP00000037669|TNF superfamily, member 2|TNF, macrophage-derived|TNF, monocyte-derived|cachectin|tumor necrosis factor alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis.
Kristina Andelid, Karolina Öst, Anders Andersson, Esha Mohamed, Zala Jevnikar, Lowie E G W Vanfleteren, Melker Göransson.
Respiratory Research 2021 Jun; 22(1):172.
Application:Neutralization, Human, Human bronchial epithelial cells.
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Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis.
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