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ABCB1 recombinant monoclonal antibody, clone MRK16

  • Catalog # : RAB00018
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  • Specification
  • Product Description:
  • Recombinant mouse monoclonal antibody raised against human ABCB1.
  • Immunogen:
  • Original antibody is raised against drug resistant K-562 cells.
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes a discontinuous extracellular epitope on human ABCB1.
  • Form:
  • Liquid
  • Purification:
  • Protein A affinity purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (1 ug/mL)
    Immunofluorescence
    Immunoprecipitation (10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.02% Proclin 300).
  • Storage Instruction:
  • Store at 4°C for up to 3 months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Antibody Species:
  • Mouse
  • Applications
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 5243
  • Gene Name:
  • ABCB1
  • Gene Alias:
  • ABC20,CD243,CLCS,GP170,MDR1,MGC163296,P-GP,PGY1
  • Gene Description:
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Gene Summary:
  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
  • Other Designations:
  • ATP-binding cassette, subfamily B, member 1,P glycoprotein 1,P-glycoprotein 1,colchicin sensitivity,doxorubicin resistance,multidrug resistance 1,multidrug resistance protein 1
  • Gene Pathway
  • Related Disease
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