ABCB1 recombinant monoclonal antibody, clone MRK16
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human P-glycoprotein.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human P-glycoprotein
Reactivity
Human
Form
Liquid
Conjugation
Unconjugated
Concentration
batch dependent
Isotype
IgG kappa
Recommend Usage
Flow cytometry
Immunofluorescence
Immunoprecipitation
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
For research use only.
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Applications
Immunofluorescence
Immunoprecipitation
Flow Cytometry
Flow-cytometry analysis of ABCB1 in HepG2 cells lysates using anti-P-glycoprotein recombinant monoclonal antibody, clone MRK16 (Cat # RAB03755). -
Gene Info — ABCB1
Entrez GeneID
5243Protein Accession#
P08183Gene Name
ABCB1
Gene Alias
ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1
Gene Description
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Omim ID
171050Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
Other Designations
ATP-binding cassette, subfamily B, member 1|P glycoprotein 1|P-glycoprotein 1|colchicin sensitivity|doxorubicin resistance|multidrug resistance 1|multidrug resistance protein 1
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