SOCS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human SOCS1.
Host
Rabbit
Theoretical MW (kDa)
23.5
Reactivity
Human, Mouse, Rabbit, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded rat lung sections, stain SOCS1 in cytoplasm DAB chromogenic reaction. -
Gene Info — SOCS1
Entrez GeneID
8651Gene Name
SOCS1
Gene Alias
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Gene Description
suppressor of cytokine signaling 1
Omim ID
603597Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
Other Designations
JAK binding protein|STAT induced SH3 protein 1|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis.
Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A.
The Journal of Experimental Medicine 2004 Jun; 199(12):1701.
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Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas.
Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, Kawanami O, Kishimoto T, Konishi N, Nakamura M, Kobayashi Y, Emi M.
Journal of Human Genetics 2003 Feb; 48(2):65.
Application:IHC-P, Human, Hepatoblastoma cells.
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A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13.
Kramer JA, Adams MD, Singh GB, Doggett NA, Krawetz SA.
Somatic Cell and Molecular Genetics 1998 Mar; 24(2):131.
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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis.
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