SOCS1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
Immunogen
A synthetic peptide corresponding to human SOCS1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SOCS1. Using SOCS1 polyclonal antibody (Cat # PAB0214) at 1 : 1000 dilution against 15 ug/lane of Ramos (A) and Raw (B) cell lysate. -
Gene Info — SOCS1
Entrez GeneID
8651Gene Name
SOCS1
Gene Alias
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Gene Description
suppressor of cytokine signaling 1
Omim ID
603597Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
Other Designations
JAK binding protein|STAT induced SH3 protein 1|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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SARS-CoV nucleocapsid protein induced apoptosis of COS-1 mediated by the mitochondrial pathway.
Zhang L, Wei L, Jiang D, Wang J, Cong X, Fei R.
Artificial Cells, Blood Substitutes, and Immobilization Biotechnology 2007 Jan; 35(2):237.
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Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P.
PNAS 2005 Aug; 102(33):11876.
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SARS-CoV nucleocapsid protein induced apoptosis of COS-1 mediated by the mitochondrial pathway.
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