PXN polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PXN.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PXN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This peptide sequence is highly conserved in rat and mouse paxillins, and is found in all three paxillin isoforms (a, b, and g).
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of A-431 cells. The blot was probed with rabbit PXN polyclonal antibody (Cat # PAB7873) at 1:500 (lane 1) & 1:2000 (lane 2).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PXN
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Interactome
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Pathway
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Disease
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Publication Reference
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A role for JNK-paxillin signaling in cell migration.
Huang C, Jacobson K, Schaller MD.
Cell Cycle 2004 Jan; 3(1):4.
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Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway.
Woodrow MA, Woods D, Cherwinski HM, Stokoe D, McMahon M.
Experimental Cell Research 2003 Jul; 287(2):325.
Application:IF, IP, WB, Mouse, NIH/3T3 cells.
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JNK phosphorylates paxillin and regulates cell migration.
Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K.
Nature 2003 Jul; 424(6945):219.
Application:WB-Tr, Human, HEK 293, MDA-MB-231 cells.
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A role for JNK-paxillin signaling in cell migration.
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