CDH5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot of human umbilical vein endothelial cells. The blots were probed with CDH5 polyclonal antibody (Cat # PAB7871) at 1:1000 (lane 1) and 1:4000 (lane2).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDH5.
Immunogen
A synthetic peptide corresponding to amino acids 770-781 of human CDH5.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This sequence has significant homology to the conserved site in rat and mouse, and has less than 50% homology with other cadherins.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of human umbilical vein endothelial cells. The blots were probed with CDH5 polyclonal antibody (Cat # PAB7871) at 1:1000 (lane 1) and 1:4000 (lane2).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDH5
Entrez GeneID
1003Protein Accession#
P33151Gene Name
CDH5
Gene Alias
7B4, CD144, FLJ17376
Gene Description
cadherin 5, type 2 (vascular endothelium)
Omim ID
601120Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq
Other Designations
7B4 antigen|VE-cadherin|cadherin 5, type 2|cadherin 5, type 2, VE-cadherin (vascular epithelium)|cd144 antigen|endothelial-specific cadherin|vascular endothelial cadherin
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Interactome
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Pathway
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Disease
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Publication Reference
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Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.
Wallez Y, Cand F, Cruzalegui F, Wernstedt C, Souchelnytskyi S, Vilgrain I, Huber P.
Oncogene 2007 Feb; 26(7):1067.
Application：IP, WB, Mouse, CHO cells.
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Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state.
Potter MD, Barbero S, Cheresh DA.
The Journal of Biological Chemistry 2005 Sep; 280(36):31906.
Application：IF, IP-WB, Mouse, CHO cells.
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Association of Csk to VE-cadherin and inhibition of cell proliferation.
Baumeister U, Funke R, Ebnet K, Vorschmitt H, Koch S, Vestweber D.
The EMBO Journal 2005 May; 24(9):1686.
Application：IF, IP-WB, Mouse, Monkey, CHO, COS-7 cells.
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Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.
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