PLCG2 (phospho Y1217) polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PLCG2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y1217 of human PLCG2.
Host
Rabbit
Theoretical MW (kDa)
150
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Imunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using PLCG2 (phospho Y1217) polyclonal antibody (Cat # PAB7766). -
Gene Info — PLCG2
Entrez GeneID
5336Protein Accession#
P16885Gene Name
PLCG2
Gene Alias
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Gene Description
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Omim ID
600220Gene Ontology
HyperlinkGene Summary
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM
Other Designations
phospholipase C gamma 2|phospholipase C, gamma 2|phospholipase C, gamma 2 (phosphatidylyinositol-specific)
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Interactome
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Pathway
- B cell receptor signaling pathway
- Calcium signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Inositol phosphate metabolism
- Leukocyte transendothelial migration
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Disease
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