PLCG2 recombinant monoclonal antibody, clone PLCG2Y759-G3 (PE)
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More Files
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Flow Cytometry
Flow cytometric analysis of Ramos cells unstained treated with imatinib (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using phospho-PLCγ2 (Tyr759) antibody PLCG2Y759-G3 PE conjugate.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PLCG2.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCg2.
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Conjugation Note
PE
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Ramos cells unstained treated with imatinib (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using phospho-PLCγ2 (Tyr759) antibody PLCG2Y759-G3 PE conjugate. -
Gene Info — PLCG2
Entrez GeneID
5336Protein Accession#
P16885Gene Name
PLCG2
Gene Alias
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Gene Description
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Omim ID
600220Gene Ontology
HyperlinkGene Summary
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM
Other Designations
phospholipase C gamma 2|phospholipase C, gamma 2|phospholipase C, gamma 2 (phosphatidylyinositol-specific)
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Interactome
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Pathway
- B cell receptor signaling pathway
- Calcium signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Inositol phosphate metabolism
- Leukocyte transendothelial migration
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Disease
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