COL7A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
COL7A1 polyclonal antibody (Cat # PAB7538) (0.5 ug/mL) staining of rat testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of COL7A1.
Immunogen
A synthetic peptide corresponding to human COL7A1.
Sequence
C-TVQYSDDPRTEF
Host
Goat
Theoretical MW (kDa)
295
Reactivity
Rat
Specificity
This product does not work on cryostat sections of normal human Skin.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
COL7A1 polyclonal antibody (Cat # PAB7538) (0.5 ug/mL) staining of rat testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — COL7A1
Entrez GeneID
1294Protein Accession#
NP_000085.1Gene Name
COL7A1
Gene Alias
EBD1, EBDCT, EBR1
Gene Description
collagen, type VII, alpha 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq
Other Designations
LC collagen|alpha 1 type VII collagen|collagen VII, alpha-1 polypeptide|long chain collagen
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Interactome
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Disease
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Publication Reference
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Type VII collagen is required for Ras-driven human epidermal tumorigenesis.
Ortiz-Urda S, Garcia J, Green CL, Chen L, Lin Q, Veitch DP, Sakai LY, Lee H, Marinkovich MP, Khavari PA.
Science 2005 Mar; 307(5716):1773.
Application：WB, Human, Human keratinocytes, Recombinant proteins.
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Type VII collagen is required for Ras-driven human epidermal tumorigenesis.
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