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Last updated: 2016/12/4
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RPE65 polyclonal antibody

  • Catalog # : PAB7451
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of RPE65.
  • Immunogen:
  • A synthetic peptide corresponding to human RPE65.
  • Sequence:
  • C-EVKKNARKAPQPE
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 60.9
  • Reactivity:
  • Rat
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:32000)
    Western Blot (0.5-1.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • RPE65 polyclonal antibody (Cat # PAB7451) (0.5 ug/mL) staining of rat retina lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 6121
  • Gene Name:
  • RPE65
  • Gene Alias:
  • LCA2,RP20,mRPE65,rd12,sRPE65
  • Gene Description:
  • retinal pigment epithelium-specific protein 65kDa
  • Gene Summary:
  • This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000010788,RBP-binding membrane protein,p63,retinal pigment epithelium-specific 61 kDa protein,retinal pigment epithelium-specific protein (65kD),retinitis pigmentosa 20 (autosomal recessive)
  • Gene Pathway
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