PRRX1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PRRX1.
Immunogen
A synthetic peptide corresponding to human PRRX1.
Sequence
C-GSDTPQQDNDQ
Host
Goat
Theoretical MW (kDa)
24.4, 27.3
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_008833.1, NP_073207.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PRRX1 polyclonal antibody (Cat # PAB7402) (1 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRRX1
Entrez GeneID
5396Protein Accession#
NP_008833.1;NP_073207.1Gene Name
PRRX1
Gene Alias
PHOX1, PMX1, PRX1
Gene Description
paired related homeobox 1
Omim ID
167420Gene Ontology
HyperlinkGene Summary
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq
Other Designations
OTTHUMP00000033166|OTTHUMP00000033167|homeobox protein PHOX1|paired mesoderm homeo box 1|paired mesoderm homeobox 1|paired mesoderm homeobox 1 isoform pmx-1b
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Interactome
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Disease
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Publication Reference
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The Transcription Factor Paired-Related Homeobox 1 (Prrx1) Inhibits Adipogenesis by Activating Transforming Growth Factor-β (TGFβ) Signaling.
Du B, Cawthorn WP, Su A, Doucette CR, Yao Y, Hemati N, Kampert S, McCoin C, Broome DT, Rosen CJ, Yang G, MacDougald OA.
The Journal of Biological Chemistry 2013 Feb; 288(5):3036.
Application:WB-Tr, Mouse, 3T3-L1 cells.
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Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.
Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y, Park YM.
Cancer Research 2007 Jan; 67(2):546.
Application:WB-Ce, Human, A-549 cells.
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The Transcription Factor Paired-Related Homeobox 1 (Prrx1) Inhibits Adipogenesis by Activating Transforming Growth Factor-β (TGFβ) Signaling.
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