GAB2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
GAB2 polyclonal antibody (Cat # PAB7265) (0.5 ug/mL) staining of K-562 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GAB2.
Immunogen
A synthetic peptide corresponding to human GAB2.
Sequence
C-QVDKEKTQALQN
Host
Goat
Theoretical MW (kDa)
74.5, 70
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_536739.1, NP_0.36428.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
GAB2 polyclonal antibody (Cat # PAB7265) (0.5 ug/mL) staining of K-562 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GAB2
Entrez GeneID
9846Protein Accession#
NP_536739.1;NP_0.36428.1Gene Name
GAB2
Gene Alias
KIAA0571
Gene Description
GRB2-associated binding protein 2
Omim ID
606203Gene Ontology
HyperlinkGene Summary
This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
Grb2-associated binder 2
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Interactome
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Pathway
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Disease
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Publication Reference
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A role for the scaffolding adapter GAB2 in breast cancer.
Bentires-Alj M, Gil SG, Chan R, Wang ZC, Wang Y, Imanaka N, Harris LN, Richardson A, Neel BG, Gu H.
Nature Medicine 2006 Jan; 12(1):114.
Application：IHC, WB-Tr, Human, HEK 293T, MCF-10A cells.
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A role for the scaffolding adapter GAB2 in breast cancer.
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