NR4A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
NR4A1 polyclonal antibody (Cat # PAB7103) (2 ug/mL) staining of human thyroid lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NR4A1.
Immunogen
A synthetic peptide corresponding to human NR4A1.
Sequence
C-GRLPSKPKQPPDAS
Host
Goat
Theoretical MW (kDa)
64.5
Reactivity
Human
Specificity
This antibody is expected to recognize isoform a (NP_002126.2 and NP_775180.1) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NR4A1 polyclonal antibody (Cat # PAB7103) (2 ug/mL) staining of human thyroid lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NR4A1
Entrez GeneID
3164Protein Accession#
NP_002126.2;NP_775180.1Gene Name
NR4A1
Gene Alias
GFRP1, HMR, MGC9485, N10, NAK-1, NGFIB, NP10, NUR77, TR3
Gene Description
nuclear receptor subfamily 4, group A, member 1
Omim ID
139139Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
TR3 orphan receptor|early response protein NAK1|growth factor-inducible nuclear protein N10|hormone receptor|orphan nuclear receptor HMR|steroid receptor TR3
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Interactome
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Pathway
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Disease
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Publication Reference
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Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77.
Kiss I, Oskolas H, Toth R, Bouillet P, Toth K, Fulop A, Scholtz B, Ledent C, Fesus L, Szondy Z.
European Journal of Immunology 2006 Jun; 36(6):1559.
Application：Func, WB-Ce, Mouse, Mouse thymocytes.
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Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77.
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