NOD2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NOD2.
Immunogen
A synthetic peptide corresponding to human NOD2.
Sequence
KFRFTDRERHCSPTD
Host
Goat
Theoretical MW (kDa)
115
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
NOD2 polyclonal antibody (Cat # PAB7102) (0.1 ug/mL) staining of human peripheral blood mononucleocyte lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NOD2
Entrez GeneID
64127Protein Accession#
NP_071445.1Gene Name
NOD2
Gene Alias
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Gene Description
nucleotide-binding oligomerization domain containing 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq
Other Designations
NLR family, CARD domain containing 2|NOD-like receptor C2|OTTHUMP00000164224|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-bin
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Interactome
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Disease
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Publication Reference
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Paneth cells: leukocyte-like mediators of innate immunity in the intestine.
Keshav S.
Journal of Leukocyte Biology 2006 Sep; 80(3):500.
Application:IHC, Human, Intestine.
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Paneth cells: leukocyte-like mediators of innate immunity in the intestine.
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