NOD2 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NOD2.
Immunogen
A synthetic peptide corresponding to amino acids 582-600 of human NOD2/CARD15.
Sequence
LGFLVRAKGVVPGSTAPLE
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NOD2. Using NOD2 polyclonal antibody (Cat # PAB0265) at 1 : 2000. 30 ug total protein was loaded per lane. Samples from human tumor cell lines : PPC-1 (prostate carcinoma) , NCI-H226 and NCI-H332M (lung carcinoma) , SF-268 (glioblastoma) , UO-31 and A498 (renal/kidney carcinoma) , SK-MEL-5 and SK-MEL-28 (melanoma) , and MCF-7 (breast carcinoma) . Lymphoma is from a cell line generated from a tumor growing in nude mice following injection of primary human lymphoma cells.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded normal human colon stained for NOD2 expression. Using NOD2 polyclonal antibody (Cat # PAB0265) at 1 : 2000. A, tissue core from a colon tissue microarray. A1, high magnification of A. Hematoxylin-eosin counterstain.Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — NOD2
Entrez GeneID
64127Gene Name
NOD2
Gene Alias
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Gene Description
nucleotide-binding oligomerization domain containing 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq
Other Designations
NLR family, CARD domain containing 2|NOD-like receptor C2|OTTHUMP00000164224|caspase recruitment domain family, member 15|caspase recruitment domain protein 15|inflammatory bowel disease protein 1|nucleotide-binding oligomerization domain 2|nucleotide-bin
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Interactomes
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Diseases
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