GRIN1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GRIN1.
Immunogen
A synthetic peptide corresponding to human GRIN1.
Sequence
C-TQERVNNSNKKE
Host
Goat
Theoretical MW (kDa)
99.3, 101, 105
Reactivity
Rat
Specificity
This antibody is expected to recognize all three reported isoforms (NP_000823.4, NP_067544.1, NP_015566.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000)
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GRIN1 polyclonal antibody (Cat # PAB7074) (2 ug/mL) staining of rat brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRIN1
Entrez GeneID
2902Protein Accession#
NP_000823.4;NP_067544.1;NP_015566.1Gene Name
GRIN1
Gene Alias
NMDA1, NMDAR1, NR1
Gene Description
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Omim ID
138249Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
N-methyl-D-aspartate receptor channel, subunit zeta-1|NMDA receptor 1|OTTHUMP00000022678|glutamate [NMDA] receptor subunit zeta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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The role of CA3 hippocampal NMDA receptors in paired associate learning.
Rajji T, Chapman D, Eichenbaum H, Greene R.
Journal of Neuroscience 2006 Jan; 26(3):908.
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The role of CA3 hippocampal NMDA receptors in paired associate learning.
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