GRIN1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of GRIN1 expression from rat brain tissue lyate with GRIN1 polyclonal antibody (Cat # PAB12310).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining in rat brain tissue using GRIN1 polyclonal antibody (Cat # PAB12310).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRIN1.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human GRIN1.
Host
Rabbit
Theoretical MW (kDa)
105
Reactivity
Human, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of GRIN1 expression from rat brain tissue lyate with GRIN1 polyclonal antibody (Cat # PAB12310).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining in rat brain tissue using GRIN1 polyclonal antibody (Cat # PAB12310). -
Gene Info — GRIN1
Entrez GeneID
2902Gene Name
GRIN1
Gene Alias
NMDA1, NMDAR1, NR1
Gene Description
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Omim ID
138249Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
N-methyl-D-aspartate receptor channel, subunit zeta-1|NMDA receptor 1|OTTHUMP00000022678|glutamate [NMDA] receptor subunit zeta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).
Zimmer M, Fink TM, Franke Y, Lichter P, Spiess J.
Gene 1995 Jul; 159(2):219.
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Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel.
Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, Kobayashi H, Mishina M, Tsuji S.
Biochemical and Biophysical Research Communications 1993 Dec; 197(2):922.
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Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively.
Collins C, Duff C, Duncan AM, Planells-Cases R, Sun W, Norremolle A, Michaelis E, Montal M, Worton R, Hayden MR.
Genomics 1993 Jul; 17(1):237.
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Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).
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