SCN5A polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SCN5A.
Immunogen
A synthetic peptide corresponding to human SCN5A.
Sequence
C-ETDDQSPEKIN
Host
Goat
Theoretical MW (kDa)
227, 225, 223, 221
Specificity
This antibody is expected to recognize both reported isoforms (NP_000326 and NP_932173).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Immunohistochemistry (8-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
PAB6860 (8 ug/mL) staining of paraffin embedded Human Cortex. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SCN5A
Entrez GeneID
6331Protein Accession#
NP_932173.1;NP_000326Gene Name
SCN5A
Gene Alias
CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1
Gene Description
sodium channel, voltage-gated, type V, alpha subunit
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
cardiac sodium channel alpha subunit|sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)|voltage-gated sodium channel type V alpha
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Interactome
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Disease
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Publication Reference
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Sodium channel mutations and susceptibility to heart failure and atrial fibrillation.
Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, Horton SC, Rodeheffer RJ, Anderson JL.
JAMA 2005 Jan; 293(4):447.
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Sodium channel mutations and susceptibility to heart failure and atrial fibrillation.
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