SERPINI2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
SERPINI2 polyclonal antibody (Cat # PAB6764) (0.3 ug/mL) staining of human pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SERPINI2 polyclonal antibody (Cat # PAB6764) (3 ug/mL) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SERPINI2.
Immunogen
A synthetic peptide corresponding to internal region of human SERPINI2.
Sequence
C-KGDWKQKFRKEDTQ
Host
Goat
Theoretical MW (kDa)
46.1, 47.4
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_006208.1, NP_00101230.3.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SERPINI2 polyclonal antibody (Cat # PAB6764) (0.3 ug/mL) staining of human pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SERPINI2 polyclonal antibody (Cat # PAB6764) (3 ug/mL) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with citrate buffer pH 6, HRP-stainingEnzyme-linked Immunoabsorbent Assay
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Gene Info — SERPINI2
Entrez GeneID
5276Protein Accession#
NP_006208.1;NP_00101230.3.1Gene Name
SERPINI2
Gene Alias
MEPI, PANCPIN, PI14, TSA2004
Gene Description
serpin peptidase inhibitor, clade I (pancpin), member 2
Omim ID
605587Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq
Other Designations
myoepithelium-derived serine protease inhibitor|protease inhibitor 14|serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2|serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
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Interactome
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Disease
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Publication Reference
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Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells.
Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y.
Genes, Chromosomes & Cancer 1998 Jul; 22(3):179.
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Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells.
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