RGS18 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
RGS18 polyclonal antibody (Cat # PAB6634, 1 ug/mL) staining of human peripheral blood mononucleocytes lysate (35 ug protein in RIPA buffer) . Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RGS18.
Immunogen
A synthetic peptide corresponding to human RGS18.
Sequence
CNEFQDVQSDVAIWL
Host
Goat
Theoretical MW (kDa)
27.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
RGS18 polyclonal antibody (Cat # PAB6634, 1 ug/mL) staining of human peripheral blood mononucleocytes lysate (35 ug protein in RIPA buffer) . Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — RGS18
Entrez GeneID
64407Protein Accession#
NP_570138Gene Name
RGS18
Gene Alias
RGS13
Gene Description
regulator of G-protein signaling 18
Omim ID
607192Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
OTTHUMP00000033590|regulator of G-protein signalling 13|regulator of G-protein signalling 18
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Interactome
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Disease
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Publication Reference
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Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.
Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF.
The Journal of Biological Chemistry 2001 Jan; 276(2):915.
Application：WB-Ti, Mouse, Spleen, Bone marrow, Thymus, .
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Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.
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