HSPB8 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
HSPB8 polyclonal antibody (Cat # PAB6266) staining (1 ug/mL) of human muscle lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HSPB8.
Immunogen
A synthetic peptide corresponding to human HSPB8.
Sequence
NELPQDSQEVTCT
Host
Goat
Theoretical MW (kDa)
21.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HSPB8 polyclonal antibody (Cat # PAB6266) staining (1 ug/mL) of human muscle lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSPB8
Entrez GeneID
26353Protein Accession#
NP_055180.1Gene Name
HSPB8
Gene Alias
CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
Gene Description
heat shock 22kDa protein 8
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq
Other Designations
E2-induced gene 1|heat shock 27kDa protein 8|heat shock protein beta-8|protein kinase H11|small stress protein-like protein HSP22
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Interactome
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Disease
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Publication Reference
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HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).
Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ.
The Journal of Biological Chemistry 2001 Jul; 276(29):26753.
Application：WB-Tr, Monkey, COS-7 cells.
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HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).
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