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Last updated: 2016/12/4
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SOCS1 polyclonal antibody

  • Catalog # : PAB6012
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of SOCS1.
  • Immunogen:
  • A synthetic peptide corresponding to C terminus of human SOCS1.
  • Sequence:
  • C-VLRDYLSSFPFQI
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 23.6
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:4000)
    Western blot (1-3 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • SOCS1 polyclonal antibody (Cat # PAB6012) staining (2 ug/mL) of mouse spleen lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • HEK293 overexpressing SOCS1 and probed with SOCS1 polyclonal antibody (Cat # PAB6012) (mock transfection in lane 2) .
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • SOCS1 polyclonal antibody (Cat # PAB6012, 2.5 ug/mL) staining of paraffin embedded human kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8651
  • Gene Name:
  • SOCS1
  • Gene Alias:
  • CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3
  • Gene Description:
  • suppressor of cytokine signaling 1
  • Gene Summary:
  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
  • Other Designations:
  • JAK binding protein,STAT induced SH3 protein 1,Tec-interacting protein 3,cytokine-inducible SH2 protein 1
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