Western blot analysis of PRKCQ polyclonal antibody (Cat # PAB4547) in placenta lysate . PRKCQ (Arrow) was detected using purified PRKCQ polyclonal antibody (Cat # PAB4547) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PRKCQ polyclonal antibody (Cat # PAB4547) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq