Western blot analysis of IL1R1 polyclonal antibody (Cat # PAB4455) in HL-60 cell line lysates (35 ug/lane). IL1R1 (arrow) was detected using the purified IL1R1 polyclonal antibody (Cat # PAB4455) (1 : 60 dilution).
Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with IL1R1 polyclonal antibody (Cat # PAB4455) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated .
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq