PTP4A1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of mouse spleen tissue lysate (35 ug/lane) with PTP4A1 polyclonal antibody (Cat # PAB4121).
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant PTP4A1.
Immunogen
Recombinant protein corresponding to full length human PTP4A1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse spleen tissue lysate (35 ug/lane) with PTP4A1 polyclonal antibody (Cat # PAB4121).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTP4A1
Entrez GeneID
7803Protein Accession#
NP_003454.1Gene Name
PTP4A1
Gene Alias
DKFZp779M0721, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1
Gene Description
protein tyrosine phosphatase type IVA, member 1
Omim ID
601585Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells. [provided by RefSeq
Other Designations
OTTHUMP00000016675|Protein tyrosine phosphatase IVA1|protein tyrosine phosphatase type IVA protein 1
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Interactome
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Disease
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Publication Reference
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Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms.
Jeong DG, Kim SJ, Kim JH, Son JH, Park MR, Lim SM, Yoon TS, Ryu SE.
Journal of Molecular Biology 2005 Jan; 345(2):401.
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Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases.
Werner SR, Lee PA, DeCamp MW, Crowell DN, Randall SK, Crowell PL.
Cancer Letters 2003 Dec; 202(2):201.
Application：WB, Human, PRL-1 cells.
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The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis.
Wang J, Kirby CE, Herbst R.
The Journal of Biological Chemistry 2002 Nov; 277(48):46659.
Application：IF, WB-Ce, Human, HeLa cells.
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Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms.
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