PTPN9 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The PTPN9 polyclonal antibody (Cat # PAB4083) is used in Western blot to detect PTPN9 in A-549 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PTPN9 polyclonal antibody (Cat # PAB4083) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTPN9.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PTPN9.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PTPN9 polyclonal antibody (Cat # PAB4083) is used in Western blot to detect PTPN9 in A-549 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PTPN9 polyclonal antibody (Cat # PAB4083) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPN9
Entrez GeneID
5780Protein Accession#
P43378Gene Name
PTPN9
Gene Alias
MEG2, PTPMEG2
Gene Description
protein tyrosine phosphatase, non-receptor type 9
Omim ID
600768Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq
Other Designations
PTPase-MEG2|protein-tyrosine phosphatase MEG2
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Interactomes
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Publication Reference
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Purification and characterization of protein tyrosine phosphatase PTP-MEG2.
Qi Y, Zhao R, Cao H, Sui X, Krantz SB, Zhao ZJ.
Journal of Cellular Biochemistry 2002 Jan; 86(1):79.
Application：WB-Tr, Human, HEK 293 cells, Recombinant protein.
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Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides.
Kruger JM, Fukushima T, Cherepanov V, Borregaard N, Loeve C, Shek C, Sharma K, Tanswell AK, Chow CW, Downey GP.
The Journal of Biological Chemistry 2002 Jan; 277(4):2620.
Application：IF, WB-Tr, Human, Neutrophils, U-937 cells.
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Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.
Gu M, Warshawsky I, Majerus PW.
PNAS 1992 Apr; 89(7):2980.
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Purification and characterization of protein tyrosine phosphatase PTP-MEG2.
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