KCNIP3 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of mouse heart tissue lysate (35 ug/lane) with KCNIP3 polyclonal antibody (Cat # PAB3618).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with KCNIP3 polyclonal antibody (Cat # PAB3618) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brainreacted with KCNIP3 polyclonal antibody (Cat # PAB3618), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KCNIP3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human KCNIP3.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:10-50)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse heart tissue lysate (35 ug/lane) with KCNIP3 polyclonal antibody (Cat # PAB3618).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with KCNIP3 polyclonal antibody (Cat # PAB3618) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brainreacted with KCNIP3 polyclonal antibody (Cat # PAB3618), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Immunofluorescence
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Gene Info — KCNIP3
Entrez GeneID
30818Protein Accession#
Q9Y2W7Gene Name
KCNIP3
Gene Alias
CSEN, DREAM, KCHIP3, MGC18289
Gene Description
Kv channel interacting protein 3, calsenilin
Omim ID
604662Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
A-type potassium channel modulatory protein 3|DRE-antagonist modulator|Kv channel interacting protein 3|calsenilin, presenilin-binding protein, EF hand transcription factor|potassium channel interacting protein 3
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Interactome
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Disease
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Publication Reference
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Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3.
Choi EK, Miller JS, Zaidi NF, Salih E, Buxbaum JD, Wasco W.
Molecular and Cellular Neurosciences 2003 Jul; 23(3):495.
Application：IP-WB, WB-Tr, Human, H4, SY5Y cells.
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Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients.
Hong YM, Jo DG, Lee MC, Kim SY, Jung YK.
Neuroscience Letters 2003 Apr; 340(1):33.
Application：IHC-P, WB, Human, Mouse, Brains.
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PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex.
Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD.
The Journal of Neuroscience 2002 Dec; 22(23):10123.
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Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3.
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