GJD2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The GJD2 polyclonal antibody (Cat # PAB3597) is used in Western blot to detect GJD2 in placenta tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GJD2 polyclonal antibody (Cat # PAB3597) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GJD2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GJD2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The GJD2 polyclonal antibody (Cat # PAB3597) is used in Western blot to detect GJD2 in placenta tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GJD2 polyclonal antibody (Cat # PAB3597) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — GJD2
Entrez GeneID
57369Protein Accession#
Q9UKL4Gene Name
GJD2
Gene Alias
CX36, GJA9, MGC138315, MGC138319
Gene Description
gap junction protein, delta 2, 36kDa
Omim ID
607058Gene Ontology
HyperlinkGene Summary
This gene is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Connexins associate in groups of 6 and are organized radially around a central pore to form connexons. Each gap junction intercellular channel is formed by the conjunction of 2 connexons. [provided by RefSeq
Other Designations
connexin 36|connexin-36|gap junction alpha-9 protein|gap junction protein, alpha 9, 36kDa
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Interactome
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Pathway
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Disease
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Publication Reference
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Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family.
de Brouwer AP, Pennings RJ, Roeters M, Van Hauwe P, Astuto LM, Hoefsloot LH, Huygen PL, van den Helm B, Deutman AF, Bork JM, Kimberling WJ, Cremers FP, Cremers CW, Kremer H.
Human Genetics 2003 Feb; 112(2):156.
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Structure, chromosomal localization, and brain expression of human Cx36 gene.
Belluardo N, Trovato-Salinaro A, Mudo G, Hurd YL, Condorelli DF.
Journal of Neuroscience Research 1999 Sep; 57(5):740.
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Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family.
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