TRAF2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRAF2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human TRAF2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of TRAF2 (arrow) using rabbit TRAF2 polyclonal antibody (Cat # PAB3506). 293 cell lysates (2 ug/lane) either nontransfected (c) or transiently transfected with the TRAF2 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with TRAF2 polyclonal antibody (Cat # PAB3506) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. -
Gene Info — TRAF2
Entrez GeneID
7186Protein Accession#
NP_663770;Q12933Gene Name
TRAF2
Gene Alias
MGC:45012, TRAP, TRAP3
Gene Description
TNF receptor-associated factor 2
Omim ID
601895Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq
Other Designations
OTTHUMP00000022625|OTTHUMP00000064745|tumor necrosis factor type 2 receptor associated protein 3
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Interactome
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Publication Reference
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Unique signaling properties of CTAR1 in LMP1-mediated transformation.
Mainou BA, Everly DN Jr, Raab-Traub N.
Journal of Virology 2007 Sep; 81(18):9680.
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TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.
Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C.
Molecular Immunology 2008 Jan; 45(1):76.
Application:IP, Human, K562-CD40L treated Ramos cells.
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Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Morrison BH, Bauer JA, Lupica JA, Tang Z, Schmidt H, DiDonato JA, Lindner DJ.
The Journal of Biological Chemistry 2007 May; 282(21):15349.
Application:WB, Human, OVCAR-3 cells.
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Unique signaling properties of CTAR1 in LMP1-mediated transformation.
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