Western blot analysis of HeLa cell lysate (35 ug/lane) with PDGFRL polyclonal antibody (Cat # PAB3378).
Western Blot (Transfected lysate)
Western blot analysis of PDGFRL (arrow) using PDGFRL polyclonal antibody (Cat # PAB3378). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PDGFRL gene (Lane 2).
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PDGFRL polyclonal antibody (Cat # PAB3378) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq