PIK3CG polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIK3CG.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PIK3CG.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of K-562 cell lysate (35 ug/lane) with PIK3CG polyclonal antibody (Cat # PAB3218).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PIK3CG polyclonal antibody (Cat # PAB3218) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — PIK3CG
Entrez GeneID
5294Protein Accession#
NP_002640Gene Name
PIK3CG
Gene Alias
PI3CG, PI3K, PI3Kgamma, PIK3
Gene Description
phosphoinositide-3-kinase, catalytic, gamma polypeptide
Omim ID
601232Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq
Other Designations
1-phosphatidylinositol 3-kinase|PI3-kinase|PTDINS-3-kinase|p110-gamma|phosphatidylinositol 3 kinase gamma, p110 gamma|phosphatidylinositol 3-kinase catalytic 110-kD gamma|phosphatidylinositol 3-kinase, catalytic, gamma polypeptide|phosphoinositide-3-kinas
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Interactome
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Pathway
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Disease
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Publication Reference
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Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation.
Resendiz JC, Feng S, Ji G, Francis KA, Berndt MC, Kroll MH.
Molecular Pharmacology 2003 Mar; 63(3):639.
Application:IP, WB, Human, Human platelets.
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Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.
Francois F, Klotman ME.
Journal of Virology 2003 Feb; 77(4):2539.
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Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells.
Chandrasekar N, Mohanam S, Gujrati M, Olivero WC, Dinh DH, Rao JS.
Oncogene 2003 Jan; 22(3):392.
Application:WB, Human, SNB19 cells.
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Purinergic P2Y12 receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation.
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