Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LDLRAP1 polyclonal antibody (Cat # PAB3210) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq
LDL receptor adaptor protein,OTTHUMP00000008526,autosomal recessive hypercholesterolemia protein