CDKN1B (phospho T198) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of human CDKN1B (phospho T198).
Immunogen
A synthetic peptide corresponding to amino acids 140-220 of human CDKN1B (phospho T198).
Host
Rabbit
Reactivity
Human
Specificity
This antibody detects endogenous levels of CDKN1B protein only when phosphorylated at T198.
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
ELISA (1:20000)
Western Blot (1:500-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 0.5% BSA and 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis of human VEC cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDKN1B
Entrez GeneID
1027Protein Accession#
P46527Gene Name
CDKN1B
Gene Alias
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene Description
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Ontology
HyperlinkGene Summary
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
Other Designations
cyclin-dependent kinase inhibitor 1B
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Interactome
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Pathway
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Disease
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