MSLN polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human MSLN.
Immunogen
Recombinant protein corresponding to human MSLN.
Sequence
RQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQH
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of CAPAN-2 cell lysate with MSLN polyclonal antibody (Cat # PAB31472).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human fallopian tube with MSLN polyclonal antibody (Cat # PAB31472) shows moderate cytoplasmic and membranous positivity in glandular cells. -
Gene Info — MSLN
Entrez GeneID
10232Protein Accession#
Q13421Gene Name
MSLN
Gene Alias
CAK1, MPF, SMR
Gene Description
mesothelin
Omim ID
601051Gene Ontology
HyperlinkGene Summary
An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
megakaryocyte potentiating factor
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Interactome
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Disease
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Publication Reference
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In vivo imaging of human malignant mesothelioma grown orthotopically in the peritoneal cavity of nude mice.
Feng M, Zhang J, Anver M, Hassan R, Ho M.
Journal of Cancer 2011 Mar; 2:123.
Application:Flow Cyt, IHC-P, Human, Mouse, LMB-H226-GL cells, Mouse peritoneal cavity, NCI-H226 cells.
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In vivo imaging of human malignant mesothelioma grown orthotopically in the peritoneal cavity of nude mice.
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