PDE5A polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human duodenum shows moderate cytoplasmic positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol. Antibody staining is shown in green.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human PDE5A.
Immunogen
Recombinant protein corresponding to amino acids 303-442 of human PDE5A.
Sequence
FAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGN
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C for short term storage. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human duodenum shows moderate cytoplasmic positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol. Antibody staining is shown in green. -
Gene Info — PDE5A
Entrez GeneID
8654Protein Accession#
O76074Gene Name
PDE5A
Gene Alias
CGB-PDE, CN5A, PDE5, PDE5A1
Gene Description
phosphodiesterase 5A, cGMP-specific
Omim ID
603310Gene Ontology
HyperlinkGene Summary
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase|phosphodiesterase 5A
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Interactome
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Pathway
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Disease
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Publication Reference
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PDE5 exists in human neurons and is a viable therapeutic target for neurologic disease.
Teich AF, Sakurai M, Patel M, Holman C, Saeed F, Fiorito J, Arancio O.
Journal of Alzheimer's Disease 2016 Jan; 52(1):295.
Application：IHC-P, WB-Ti, Human, Human brain.
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PDE5 exists in human neurons and is a viable therapeutic target for neurologic disease.
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