ITCH polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant human ITCH.
Immunogen
Recombinant protein corresponding to human ITCH.
Sequence
LKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human duodenum with ITCH polyclonal antibody (Cat # PAB30919) shows strong positivity in glandular cells. -
Gene Info — ITCH
Entrez GeneID
83737Protein Accession#
Q96J02Gene Name
ITCH
Gene Alias
AIF4, AIP4, NAPP1, dJ468O1.1
Gene Description
itchy E3 ubiquitin protein ligase homolog (mouse)
Omim ID
606409Gene Ontology
HyperlinkGene Summary
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq
Other Designations
NFE2-associated polypeptide 1|atrophin-1 interacting protein 4|dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))|itchy homolog E3 ubiquitin protein ligase|ubiquitin protein ligase ITCH
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Interactomes
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Pathways
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Publication Reference
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Novel signatures of cancer-associated fibroblasts.
Bozóky B, Savchenko A, Csermely P, Korcsmáros T, Dúl Z, Pontén F, Székely L, Klein G.
International Journal of Cancer 2013 Jul; 133(2):286.
Application:IHC, Human, Basal cell carcinoma, Breast cancer, Colon cancer, Lung cancer, Skin cancer.
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Novel signatures of cancer-associated fibroblasts.
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