ITCH recombinant monoclonal antibody, clone 9C3
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: K562 whole cell lysate; Lane 2: U-251 whole cell lysate; Lane 3: THP-1 whole cell lysate.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ITCH.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human ITCH.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: K562 whole cell lysate; Lane 2: U-251 whole cell lysate; Lane 3: THP-1 whole cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ITCH
Entrez GeneID
83737Protein Accession#
Q96J02Gene Name
ITCH
Gene Alias
AIF4, AIP4, NAPP1, dJ468O1.1
Gene Description
itchy E3 ubiquitin protein ligase homolog (mouse)
Omim ID
606409Gene Ontology
HyperlinkGene Summary
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq
Other Designations
NFE2-associated polypeptide 1|atrophin-1 interacting protein 4|dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))|itchy homolog E3 ubiquitin protein ligase|ubiquitin protein ligase ITCH
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Interactome
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Pathway
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