CD46 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with CD46 polyclonal antibody (Cat # PAB30884) shows distinct membranous positivity in glandular cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human CD46.
Immunogen
Recombinant protein corresponding to human CD46.
Sequence
NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with CD46 polyclonal antibody (Cat # PAB30884) shows distinct membranous positivity in glandular cells. -
Gene Info — CD46
Entrez GeneID
4179Protein Accession#
P15529Gene Name
CD46
Gene Alias
MCP, MGC26544, MIC10, TLX, TRA2.10
Gene Description
CD46 molecule, complement regulatory protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD46 antigen, complement regulatory protein|OTTHUMP00000034577|OTTHUMP00000034622|OTTHUMP00000034623|OTTHUMP00000034624|OTTHUMP00000034625|OTTHUMP00000034626|OTTHUMP00000034706|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofacto
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Interactome
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Pathway
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Disease
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Publication Reference
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Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5.
Toivonen R, Koskenvuo J, Merentie M, Söderström M, Ylä-Herttuala S, Savontaus M.
Virology Journal 2012 Nov; 9:296.
Application：IHC-P, Human, Mouse, Human hearts, Mouse hearts.
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Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5.
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