Products

Western Blot (Cell lysate)

Western blot analysis of Hela whole cell lysate with CD46 recombinant monoclonal antibody, clone 7D12 (Cat # RAB07545).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical analysis of paraffin-embedded human breast cancer with CD46 recombinant monoclonal antibody, clone 7D12 (Cat # RAB07545) on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

4179

Protein Accession#

P15529

Gene Name

CD46

Gene Alias

MCP, MGC26544, MIC10, TLX, TRA2.10

Gene Description

CD46 molecule, complement regulatory protein

Omim ID

120920 235400

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq

Other Designations

CD46 antigen, complement regulatory protein|OTTHUMP00000034577|OTTHUMP00000034622|OTTHUMP00000034623|OTTHUMP00000034624|OTTHUMP00000034625|OTTHUMP00000034626|OTTHUMP00000034706|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofacto